Cytokinesis: GAGs Form the Walls that Separate Our Parts
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منابع مشابه
Cytokinesis: GAGs Form the Walls that Separate Our Parts
Cytokinesis, the final step of cell division, involves the formation of membranous barriers that partition cytosol and organelles between the resultant daughter cells. Recent studies reveal a crucial role for the extracellular glycosaminoglycan chondroitin in the completion of the cleavage furrow in dividing Caenorhabditis elegans embryos.
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One model for the timing of cytokinesis is based on findings that p34(cdc2) can phosphorylate myosin regulatory light chain (LC20) on inhibitory sites (serines 1 and 2) in vitro (Satterwhite, L.L., M.H. Lohka, K.L. Wilson, T.Y. Scherson, L.J. Cisek, J.L. Corden, and T.D. Pollard. 1992. J. Cell Biol. 118:595-605), and this inhibition is proposed to delay cytokinesis until p34(cdc2) activity fall...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2003
ISSN: 0960-9822
DOI: 10.1016/j.cub.2003.08.048